About CelCarin

When the body is fighting infections, or is under stress, it needs additional new cells to resist the infection. CelCarin contains a unique, proven formula of natural, concentrated nucleotides and RNA building blocks, which speed up the process of creating new defence cells, essential for assisting the recovery process. Since the discovery that mother’s breast milk contains high amounts of nucleotides, the leading
brands of formula milk have been including supplementary nucleotides in their products to help support growth, development and immunity. So, what’s good for baby should be good for adult too.

NUCLEOTIDE SUPPORTS IMMUNE STATUS OF ATHELETES UNDER ENDURANCE EXERCISE
Research by Prof. Lars McNaughton, University of Bath, 2002.
McNaughton, L. / Journal of Sports Medicine and Physical Fitness (2005 pending)
- The effects of a nucleotide supplement on the immune system and metabolic response to short term, high intensity exercise
- The effects of a nucleotide supplement on salivary IgA and Cortisol after moderate endurance exercise.

STRESS CHEMICAL BUILD-UP Lactate build-up in the blood of athletes The build-up of lactate was 7 times lower for the nucleotide group active, after 90 minutes endurance exercise. Generally, this means that athletes would be able to train longer and harder. Cortisol build-up after 90 minutes endurance exercise The build-up of cortisol levels was 10% less for the athletes on nucleotides. Cortisol is a hormone released in high levels during stress activities, and attaches itself to the immune system’s disease-fighting cells. With a load of cortisol on its back, an immune cell has a harder time doing its job.
IMMUNE SYSTEM SUPPRESSION Antibody titre levels (IgA) after 90 minutes endurance exercise The antibody levels for the nucleotide-supplemented athletes remained 25% higher than the placebo group after the exercise. High decreases in IgA are thought to be a reason for increased levels of Upper Respiratory Tract Infection for athletes and people suffering high levels of stress.
CONCLUSION Nucleotides reduces the release of stress related hormones and chemicals in the body, and maintains a higher level of antibodies, which enables the immune system to work more effectively. Preserving IgA levels are likely to mean that the immune system is being positively impacted, especially when an athlete is training hard. Minimal over-training can have a large impact on the health of an athlete, who becomes prone to infections such as colds and flu. Maintaining the immune status of an athlete is critical. Basically, if an athlete is ill, he can't train.

INFLUENCE OF NUCLEOTIDES ON IMMUNITY – COLDS AND FLU SYMPTOMS
Abstract and post presentation accepted at Complementary/Alternative Medicine (CAM) and the NHS, Scotland – 20/9/02
Clinical trial, Queen Margaret University College, Edinburgh, EH12 8TS, Scotland
Dr Isobel Davidson, Department of Dietetics, Nutrition & Biological Sciences

STUDY OBJECTIVES:
To determine whether or not supplementation with a formula of specific, concentrated nucleotides can reduce the severity of specific symptoms, secondary infections and healing time after non-induced and natural infection by cold or flu virus.

HYPOTHESIS:
There is a significant difference with nucleotide supplementation in reducing the length and severity of some specific cold or flu symptoms as compared to a placebo.

CONCLUSIONS:
As per evidence and data obtained and analyzed during/after this double blind trial, we conclude the following:
The specific nucleotide supplement product significantly reduced the following symptoms suffered as a result of a common cold or flu infection or secondary infection there from:

The severity of these symptoms was attenuated: Dry mouth, sore throat, muscle aches and headaches. Over the first 6 days of taking either nucleotide supplements or a placebo, the discomfort level was on average: Symptoms For Nucleotide supplement users Dry mouth 30 % less Store throat 20 % less Muscle aches 15 % less Headache 40 % less Higher antibody levels indicate a greater immune response. Salivary IgA (antibody) concentrations were similar at recruitment but subsequent to this were for the most part higher for the nucleotide group.

Experts Opinion

Professor Lars McNaughton, University of Hull
Jan de Vries, renowned naturopath

Professor McNaughton has conducted preliminary research into nucleotide supplements' impact on stress and the immune system, leading to published papers. Jan de Vries has been successfully recommending and selling and prescribing nucleotide supplement in his clinics since trials started. Together they have noted several key benefits of nucleotide supplements for patients:

Improved immune system
- higher levels of the antibodies responsible for fighting Upper Respiratory Tract Infection have been observed in people taking nucleotide supplements

Fewer symptoms of cold and flu
- Trials show that people taking nucleotide supplements recover from head colds in half the time compared to people not taking the supplement, and have lesser sore throat pain.

Less prone to stress-related feelings
- People taking nucleotide supplements release lesser stress hormones responsible for immune suppression.

Increased feelings of wellbeing
- individuals taking nucleotide supplements report better appetites than others not on the supplement, and are more able to take part in the activities, which they most enjoy

Heightened energy and vitality
- Nucleotide supplements enables one to achieve a better quality and longer night’s sleep - an average of one hour extra per night.

Reduced Mood Swings
- Women going through menopause experienced fewer mood swings and greater energy levels.

More Information

Deoxyribonucleic acid, DNA, which makes up the genetic material in cells, is comprised of units called nucleotides. These nucleotides are Adenosine (A), Guanosine (G), Cytidine (C) and Thymidine (T). Uridine (U) is a fifth nucleotide, which is used to make RNA, along with A, G
and C.

Nucleotides are most familiar as the building blocks of DNA and RNA. However nucleotides are by themselves or in combination with other molecules involved in almost all the activities of the cell, including catalysis, transfer of energy and mediation of hormone signals.

The growing body has an ongoing demand for new cell production, and in adults must create cells at a rate as fast as that at which its cells die. To do this, a typical cell must double its mass and duplicate all of its contents in order to produce the two new daughter cells. This multiplication of a cell starts with the doubling of the information, namely the DNA.

A normal DNA consists of 3 billion nucleotides. Only after the duplication of the DNA can the Phase start, where the two cell nuclei are formed
and the cell starts to divide in two separate cells. Providing dietary sources of nucleotides has been shown to speed up the multiplication of
certain cells.

- Both the maintenance and growth of our biological systems requires proliferation of various cells.

- This is a lengthy and complicated process, dependent on energy and supply on specific building blocks, especially nucleotides.

- Nucleic acids have immune-enhancing and tissue-regenerating and activities.

- Nucleotides are also directly linked to protein synthesis and tissue repair.

It was thought that the body could synthesize from their smaller precursor molecules sufficient nucleotides to meet its physiological demands via de novo synthetic pathways or recycle nucleotides from dead cells. Some research during the last several years indicates that this may not be completely correct. The body requires dietary nucleic acids/nucleotides to meet its physiological requirements.

These conditions include rapid growth, limited food supply and metabolic stress. Under these conditions, the metabolic demand exceeds the capacity of de novo synthesis. Under these conditions, dietary nucleotides, nucleotides and nucleic acids become conditionally essential nutrients. Dietary nucleotides may spare the energetic cost of de novo synthesis nucleotides. For years, nucleic acids and nucleotides were
not considered essential nutrients. Now these nucleotides are increasingly considered to be limiting in certain diets and for certain types of
stresses and disease.

Dietary nucleic acids are found in plant and animal foods. The dietary intake of RNA is typically about an order of magnitude greater than DNA, and is particularly present in offal such as liver and tripe, yeast extracts, fungi, lean meat and fish. The nucleotide salts disodium inosinate and disodium guanylate are present in many food products as seasoning substances, contributing to the dietary nucleotide intake. Unfortunately, today’s increasing intake of processed foods, with reduced amounts of lean meat, and restricted dietary regimes and fads, often leave a deficiency in our diet.

Interestingly, mother’s milk is a rich source of nucleic acids, especially RNA and nucleotides. The research conducted in this area of infant nutrition has led to an increasing number of infant formulas containing supplemented nucleotides. More recent adult based research has led to
some food supplements containing specific formulae of all five purified nucleotides. These products are directed for use for immune enhancement under conditions of metabolic stress, and intestinal stress and tissue regeneration to enhance intestinal balance and repair of villi.

Further information on the subject of nucleotides can be found by visiting the independent web site: